English Intern


    Originalarbeiten 2017
    • Stichler S, Jungst T, Schamel M, Zilkowski I, Kuhlmann M, Böck T, Blunk T, Teßmar J, Groll J. Thiol-ene Clickable Poly(glycidol) Hydrogels for Biofabrication. Ann Biomed Eng. 2017 Jan;45(1):273-285. doi: 10.1007/s10439-016-1633-3.
    • Braun AC, Gutmann M, Ebert R, Jakob F, Gieseler H, Lühmann T, Meinel L. Matrix Metalloproteinase Responsive Delivery of Myostatin Inhibitors. Pharm Res. 2017 Jan;34(1):58-72. doi: 10.1007/s11095-016-2038-6.
    Originalarbeiten 2016
    • Holzapfel BM, Wagner F, Martine LC, Reppenhagen S, Rudert M, Schuetz M, Denham J, Schantz JT, Hutmacher DW. Tissue engineering and regenerative medicine in musculoskeletal oncology. Cancer Metastasis Rev. 2016 Sep;35(3):475-87. doi: 10.1007/s10555-016-9635-z.
    • Schweinlin M, Rossi A, Lodes N, Lotz C, Hackenberg S, Steinke M, Walles H, Groeber F. Human barrier models for the in vitro assessment of drug delivery. Drug Deliv Transl Res. 2017 Apr;7(2):217-227. doi: 10.1007/s13346-016-0316-9.
    • Schweinlin M, Wilhelm S, Schwedhelm I, Hansmann J, Rietscher R, Jurowich C, Walles H, Metzger M. Development of an Advanced Primary Human In Vitro Model of the Small Intestine. Tissue Eng Part C Methods. 2016 Sep;22(9):873-883. Epub 2016 Aug 22.
    • Schuerlein S, Schwarz T, Krziminski S, Gätzner S, Hoppensack A, Schwedhelm I, Schweinlin M, Walles H, Hansmann J. A versatile modular bioreactor platform for Tissue Engineering. Biotechnol J. 2017 Feb;12(2). doi: 10.1002/biot.201600326. Epub 2016 Sep 26.
    • Nietzer S, Baur F, Sieber S, Hansmann J, Schwarz T, Stoffer C, Häfner H, Gasser M, Waaga-Gasser AM, Walles H, Dandekar G. Mimicking Metastases Including Tumor Stroma: A New Technique to Generate a Three-Dimensional Colorectal Cancer Model Based on a Biological Decellularized Intestinal Scaffold. Tissue Eng Part C Methods. 2016 Jul;22(7):621-35. doi: 10.1089/ten.TEC.2015.0557. Epub 2016 Jun 3.
    • Jordan MC, Zimmermann C, Gho SA, Frey SP, Blunk T, Meffert RH, Hoelscher-Doht S. Biomechanical analysis of different osteosyntheses and the combination with bone substitute in tibial head depression fractures. BMC Musculoskelet Disord. 2016 Jul 15;17:287. doi: 10.1186/s12891-016-1118-4.
    • Groll J, Boland T, Blunk T, Burdick JA, Cho DW, Dalton PD, Derby B, Forgacs G, Li Q, Mironov VA, Moroni L, Nakamura M, Shu W, Takeuchi S, Vozzi G, Woodfield TB, Xu T, Yoo JJ, Malda J. Biofabrication: reappraising the definition of an evolving field. Biofabrication. 2016 Jan 8;8(1):013001. doi: 10.1088/1758-5090/8/1/013001.
    • Kamawal Y, Steinert AF, Holzapfel BM, Rudert M, Barthel T. Case report - calcification of the medial collateral ligament of the knee with simultaneous calcifying tendinitis of the rotator cuff. BMC Musculoskelet Disord. 2016 Jul 13;17:283. doi: 10.1186/s12891-016-1147-z.
    • Rudert M, Horas K, Hoberg M, Steinert A, Holzapfel DE, Hübner S, Holzapfel BM. The Wuerzburg procedure: the tensor fasciae latae perforator is a reliable anatomical landmark to clearly identify the Hueter interval when using the minimally-invasive direct anterior approach to the hip joint. BMC Musculoskelet Disord. 2016 Feb 3;17:57. doi: 10.1186/s12891-016-0908-z.
    • Gilbert F, Böhm D, Eden L, Schmalzl J, Meffert RH, Köstler H, Weng AM, Ziegler D. Comparing the MRI-based Goutallier Classification to an experimental quantitative MR spectroscopic fat measurement of the supraspinatus muscle. BMC Musculoskelet Disord. 2016 Aug 22;17(1):355. doi: 10.1186/s12891-016-1216-3.
    • Boelch SP, Jordan MC, Meffert RH, Jansen H. Comparison of open reduction and internal fixation and primary total hip replacement for osteoporotic acetabular fractures: a retrospective clinical study. Int Orthop. 2017 Sep;41(9):1831-1837. doi: 10.1007/s00264-016-3260-x. Epub 2016 Aug 10.
    • Jordan MC, Boelch S, Jansen H, Meffert RH, Hoelscher-Doht S. Does plastic suture deformation induce gapping after tendon repair? A biomechanical comparison of different suture materials. J Biomech. 2016 Sep 6;49(13):2607-2612. doi: 10.1016/j.jbiomech.2016.05.023.
    • Uckelmann H, Blaszkiewicz S, Nicolae C, Haas S, Schnell A, Wurzer S, Wagener R, Aszodi A, Essers MA. Extracellular matrix protein Matrilin-4 regulates stress-induced HSC proliferation via CXCR4. J Exp Med. 2016 Sep 19;213(10):1961-1971. Epub 2016 Aug 29.
    • Saller MM, Huettl RE, Hanuschick P, Amend AL, Alberton P, Aszodi A, Huber AB. The role of Sema3-Npn-1 signaling during diaphragm innervation and muscle development. J Cell Sci. 2016 Sep 1;129(17):3295-308. doi: 10.1242/jcs.186015. Epub 2016 Jul 27.
    • Gronau T, Krüger K, Prein C, Aszodi A, Gronau I, Iozzo RV, Mooren FC, Clausen-Schaumann H, Bertrand J, Pap T, Bruckner P, Dreier R. Forced exercise-induced osteoarthritis is attenuated in mice lacking the small leucine-rich proteoglycan decorin. Ann Rheum Dis. 2017 Feb;76(2):442-449. doi: 10.1136/annrheumdis-2016-209319. Epub 2016 Jul 4.
    • Bongoni AK, Klymiuk N, Wolf E, Ayares D, Rieben R, Cowan PJ. Transgenic Expression of Human Thrombomodulin Inhibits HMGB1-Induced Porcine Aortic Endothelial Cell Activation. Transplantation. 2016 Sep;100(9):1871-9. doi: 10.1097/TP.0000000000001188.
    • Albl B, Haesner S, Braun-Reichhart C, Streckel E, Renner S, Seeliger F, Wolf E, Wanke R, Blutke A. Tissue Sampling Guides for Porcine Biomedical Models. Toxicol Pathol. 2016 Apr;44(3):414-20. doi: 10.1177/0192623316631023. Epub 2016 Feb 16.
    • Klymiuk N, Seeliger F, Bohlooly-Y M, Blutke A, Rudmann DG, Wolf E. Tailored Pig Models for Preclinical Efficacy and Safety Testing of Targeted Therapies. Toxicol Pathol. 2016 Apr;44(3):346-57. doi: 10.1177/0192623315609688. Epub 2015 Oct 27.
    • Cowan PJ, Ayares D, Wolf E, Cooper DK. First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--Chapter 2b: genetically modified source pigs. Xenotransplantation. 2016 Jan-Feb;23(1):32-7. doi: 10.1111/xen.12224. Epub 2016 Mar 1.
    • Kemmler W, von Stengel S, Kohl M. Exercise frequency and bone mineral density development in exercising postmenopausal osteopenic women. Is there a critical dose of exercise for affecting bone? Results of the Erlangen Fitness and Osteoporosis Prevention Study. Bone. 2016 Aug;89:1-6. doi: 10.1016/j.bone.2016.04.019. Epub 2016 Apr 21.
    • Kemmler W, Teschler M, Weissenfels A, Bebenek M, von Stengel S, Kohl M, Freiberger E, Goisser S, Jakob F, Sieber C, Engelke K. Whole-body electromyostimulation to fight sarcopenic obesity in community-dwelling older women at risk. Resultsof the randomized controlled FORMOsA-sarcopenic obesity study. Osteoporos Int. 2016 Nov;27(11):3261-3270.
    • Kemmler W, Bebenek M, Kohl M, von Stengel S. Possible different roles of exercise in preventing vertebral and hip fractures: response to comments by Sugiyama et al. Osteoporos Int. 2016 Oct;27(10):3137-8. doi: 10.1007/s00198-016-3629-0. Epub 2016 May 11.
    • Kemmler W, von Stengel S, Kohl M, Bauer J. Impact of exercise changes on body composition during the college years--a five year randomized controlled study. BMC Public Health. 2016 Jan 19;16:50. doi: 10.1186/s12889-016-2692-y.
    • Kemmler W, Wittke A, Bebenek M, Fröhlich M, von Stengel S. High Intensity Resistance Training Methods with and without Protein Supplementation to Fight Cardiometabolic Risk in Middle-Aged Males: A Randomized Controlled Trial. Biomed Res Int. 2016;2016:9705287. doi: 10.1155/2016/9705287. Epub 2016 Jan 18.
    • Kemmler W, Teschler M, Weißenfels A, Bebenek M, Fröhlich M, Kohl M, von Stengel S. Effects of Whole-Body Electromyostimulation versus High-Intensity Resistance Exercise on Body Composition and Strength: A Randomized Controlled Study. Evid Based Complement Alternat Med. 2016;2016:9236809. doi: 10.1155/2016/9236809. Epub 2016 Feb 29.
    • Pottecher P, Engelke K, Duchemin L, Museyko O, Moser T, Mitton D, Vicaut E, Adams J, Skalli W, Laredo JD, Bousson V. Prediction of Hip Failure Load: In Vitro Study of 80 Femurs Using Three Imaging Methods and Finite Element Models-The European Fracture Study (EFFECT). Radiology. 2016 Sep;280(3):837-47. doi: 10.1148/radiol.2016142796. Epub 2016 Apr 14.
    • Museyko O, Bousson V, Adams J, Laredo JD, Engelke K. QCT of the proximal femur--which parameters should be measured to discriminate hip fracture? Osteoporos Int. 2016 Mar;27(3):1137-47. doi: 10.1007/s00198-015-3324-6. Epub 2015 Sep 28.
    • Ritt M, Bollheimer LC, Sieber CC, Gaßmann KG. Prediction of one-year mortality by five different frailty instruments: A comparative study in hospitalized geriatric patients. Arch Gerontol Geriatr. 2016 Sep-Oct;66:66-72. doi: 10.1016/j.archger.2016.05.004. Epub 2016 May 19.
    • Wirth R, Streicher M, Smoliner C, Kolb C, Hiesmayr M, Thiem U, Sieber CC, Volkert D. The impact of weight loss and low BMI on mortality of nursing home residents - Results from the nutritionDay in nursing homes. Clin Nutr. 2016 Aug;35(4):900-6. doi: 10.1016/j.clnu.2015.06.003. Epub 2015 Jun 19.
    • Christner S, Ritt M, Volkert D, Wirth R, Sieber CC, Gaßmann KG. Evaluation of the nutritional status of older hospitalised geriatric patients: a comparative analysis of a Mini Nutritional Assessment (MNA) version and the Nutritional Risk Screening (NRS 2002). J Hum Nutr Diet. 2016 Dec;29(6):704-713. doi: 10.1111/jhn.12376.
    • Scafoglieri A, Clarys JP, Bauer JM, Verlaan S, Van Malderen L, Vantieghem S,Cederholm T, Sieber CC, Mets T, Bautmans I; Provide Study Group. Predicting appendicular lean and fat mass with bioelectrical impedance analysis in older adults with physical function decline - The PROVIDE study. Clin Nutr. 2017 Jun;36(3):869-875. doi: 10.1016/j.clnu.2016.04.026. Epub 2016 Apr 28.
    • Drey M, Sieber CC, Degens H, McPhee J, Korhonen MT, Müller K, Ganse B, Rittweger J. Relation between muscle mass, motor units and type of training in master athletes. Clin Physiol Funct Imaging. 2016 Jan;36(1):70-6. doi: 10.1111/cpf.12195. Epub 2014 Oct 24.
    • Reboredo JW, Weigel T, Steinert A, Rackwitz L, Rudert M, Walles H. Investigation of Migration and Differentiation of Human Mesenchymal Stem Cells on Five-Layered Collagenous Electrospun Scaffold Mimicking Native Cartilage Structure. Adv Healthc Mater. 2016 Sep;5(17):2191-8. doi: 10.1002/adhm.201600134. Epub 2016 May 17.
    • Gutmann M, Memmel E, Braun AC, Seibel J, Meinel L, Lühmann T. Biocompatible Azide-Alkyne "Click" Reactions for Surface Decoration of Glyco-Engineered Cells. Chembiochem. 2016 May 3;17(9):866-75. doi: 10.1002/cbic.201500582. Epub 2016 Mar 21.
    • Kemmler W, von Stengel S, Engelke K, Sieber C, Freiberger E. Prevalence of sarcopenic obesity in Germany using established definitions : Baseline data of the FORMOsA study. Osteoporos Int. 2016 Jan;27(1):275-81. doi: 10.1007/s00198-015-3303-y. Epub 2015 Aug 29.
    • Kemmler W, Engelke K, von Stengel S. Long-Term Exercise and Bone Mineral Density Changes in Postmenopausal Women-Are There Periods of Reduced Effectiveness? J Bone Miner Res. 2016 Jan;31(1):215-22. doi: 10.1002/jbmr.2608. Epub 2015 Sep 3.
    Originalarbeiten 2015
    • Verlaan S, Aspray TJ, Bauer JM, Cederholm T, Hemsworth J, Hill TR, McPhee JS, Piasecki M, Seal C, Sieber CC, Ter Borg S, Wijers SL, Brandt K. Nutritional status, body composition, and quality of life in community-dwelling sarcopenic and non-sarcopenic older adults: A case-control study. Clin Nutr. 2017 Feb;36(1):267-274. doi: 10.1016/j.clnu.2015.11.013. Epub 2015 Nov 27.
    • Ritt M, Schwarz C, Kronawitter V, Delinic A, Bollheimer LC, Gassmann KG, Sieber CC. Analysis of Rockwood et Al's Clinical Frailty Scale and Fried et Al's Frailty Phenotype as Predictors of Mortality and Other Clinical Outcomes in Older Patients Who Were Admitted to a Geriatric Ward. J Nutr Health Aging. 2015;19(10):1043-8. doi: 10.1007/s12603-015-0534-8.
    • Kleinhans C, Mohan RR, Vacun G, Schwarz T, Haller B, Sun Y, Kahlig A, Kluger P, Finne-Wistrand A, Walles H, Hansmann J. A perfusion bioreactor system efficiently generates cell-loaded bone substitute materials for addressing critical size bone defects. Biotechnol J. 2015 Sep;10(11):1727-38. doi: 10.1002/biot.201400813. Epub 2015 Jun 24.
    • Gordon S, Daneshian M, Bouwstra J, Caloni F, Constant S, Davies DE, Dandekar G, Guzman CA, Fabian E, Haltner E, Hartung T, Hasiwa N, Hayden P, Kandarova H, Khare S, Krug HF, Kneuer C, Leist M, Lian G, Marx U, Metzger M, Ott K, Prieto P, Roberts MS, Roggen EL, Tralau T, van den Braak C, Walles H, Lehr CM. Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology. ALTEX. 2015;32(4):327-78. doi: 10.14573/altex.1510051.
    • Museyko O, Bousson V, Adams J, Laredo JD, Engelke K. QCT of the proximal femur-which parameters should be measured to discriminate hip fracture? Osteoporos Int. 2016 Mar;27(3):1137-47. doi: 10.1007/s00198-015-3324-6. Epub 2015 Sep 28.
    • Engelke K, Lang T, Khosla S, Qin L, Zysset P, Leslie WD, Shepherd JA, Shousboe JT. Clinical Use of Quantitative Computed Tomography-Based Advanced Techniques in the Management of Osteoporosis in Adults: the 2015 ISCD Official Positions-Part III. J Clin Densitom. 2015 Jul-Sep;18(3):393-407. doi: 10.1016/j.jocd.2015.06.010.
    • Zysset P, Qin L, Lang T, Khosla S, Leslie WD, Shepherd JA, Schousboe JT, Engelke K. Clinical Use of Quantitative Computed Tomography-Based Finite Element Analysis of the Hip and Spine in the Management of Osteoporosis in Adults: the 2015 ISCD Official Positions-Part II. J Clin Densitom. 2015 Jul-Sep;18(3):359-92. doi: 10.1016/j.jocd.2015.06.011.
    • Engelke K, Lang T, Khosla S, Qin L, Zysset P, Leslie WD, Shepherd JA, Schousboe JT. Clinical Use of Quantitative Computed Tomography (QCT) of the Hip in the Management of Osteoporosis in Adults: the 2015 ISCD Official Positions-Part I. J Clin Densitom. 2015 Jul-Sep;18(3):338-58. doi: 10.1016/j.jocd.2015.06.012.
    • Drey M, Sieber CC, Bertsch T, Bauer JM, Schmidmaier R; FiAT intervention group. Osteosarcopenia is more than sarcopenia and osteopenia alone. Aging Clin Exp Res. 2016 Oct;28(5):895-9. doi: 10.1007/s40520-015-0494-1. Epub 2015 Nov 12.
    • Kemmler W, Teschler M, Goisser S, Bebenek M, von Stengel S, Bollheimer LC, Sieber CC, Freiberger E. Prevalence of sarcopenia in Germany and the corresponding effect of osteoarthritis in females 70 years and older living in the community: results of the FORMoSA study. Clin Interv Aging. 2015 Oct 3;10:1565-73. doi: 10.2147/CIA.S89585. eCollection 2015.
    • Salb J, Lindemann U, Woodward C, Almutaseb S, Becker C, Sieber C, Freiberger E. Gait Analysis in Adults with Intellectual Disabilities Living in a Residential Facility. J Appl Res Intellect Disabil. 2017 Jan;30(1):205-210. doi: 10.1111/jar.12227.
    • Wesselsky V, Kitz C, Jakob F, Eulert J, Raab P. Description and evaluation of operative deformity correction in calcium-deficiency rickets in Kaduna, northern Nigeria. Int Orthop. 2016 Apr;40(4):653-8. doi: 10.1007/s00264-015-2911-7. Epub 2015 Jul 30.
    • Robert Kob, Claudia, Fellner, Thomas Bertsch, Astrid Wittmann, Daria Mishura, Cornel C. Sieber, Barbara Fischer, Christian Stroszczynski, Cornelius Bollheimer: Gender-specific differences in the development of sarcopenia in the rodent model of the ageing high-fat rat Journal of Cachexia, Sarcopenia and Muscle (2015)
    • Simann M, Schneider V, Le Blanc S, Dotterweich J, Zehe V, Krug M, Jakob F, Schilling T, Schütze N. Heparin affects human bone marrow stromal cell fate: Promoting osteogenic and reducing adipogenic differentiation and conversion. Bone. 2015 Sep;78:102-13. doi: 10.1016/j.bone.2015.04.039. Epub 2015 May 7.
    • Goisser S, Schrader E, Singler K, Bertsch T, Gefeller O, Biber R, Bail HJ, Sieber CC, Volkert D. Low postoperative dietary intake is associated with worse functional course in geriatric patients up to 6 months after hip fracture. Br J Nutr. 2015 Jun 28;113(12):1940-50. doi: 10.1017/S0007114515001282. Epub 2015 May 20.
    • Kiesswetter E, Schrader E, Diekmann R, Sieber CC, Volkert D. Varying Associations Between Body Mass Index and Physical and Cognitive Function in Three Samples of Older Adults Living in Different Settings. J Gerontol A Biol Sci Med Sci. 2015 Oct;70(10):1255-61. doi: 10.1093/gerona/glv048. Epub 2015 Apr 23.
    • Regensburger A, Rech J, Englbrecht M, Finzel S, Kraus S, Hecht K, Kleyer A, Haschka J, Hueber AJ, Cavallaro A, Schett G, Faustini F. A comparative analysis of magnetic resonance imaging and high-resolution peripheral quantitative computed tomography of the hand for the detection of erosion repair in rheumatoid arthritis. Rheumatology (Oxford). 2015 Sep;54(9):1573-81. doi: 10.1093/rheumatology/kev031. Epub 2015 Mar 31.
    • Kocijan R, Englbrecht M, Haschka J, Simon D, Kleyer A, Finzel S, Kraus S, Resch H, Muschitz C, Engelke K, Sticherling M, Rech J, Schett G. Quantitative and Qualitative Changes of Bone in Psoriasis and Psoriatic Arthritis Patients. J Bone Miner Res. 2015 Oct;30(10):1775-83. doi: 10.1002/jbmr.2521. Epub 2015 May 10.
    • Kob R, Bollheimer LC, Bertsch T, Fellner C, Djukic M, Sieber CC, Fischer BE. Sarcopenic obesity: molecular clues to a better understanding of its pathogenesis? Biogerontology. 2015 Feb;16(1):15-29. doi: 10.1007/s10522-014-9539-7. Epub 2014 Nov 7.
    • Goisser S, Schrader E, Singler K, Bertsch T, Gefeller O, Biber R, Bail HJ, Sieber CC, Volkert D. Malnutrition According to Mini Nutritional Assessment Is Associated With Severe Functional Impairment in Geriatric Patients Before and up to 6 Months After Hip Fracture. J Am Med Dir Assoc. 2015 Aug 1;16(8):661-7. doi: 10.1016/j.jamda.2015.03.002. Epub 2015 Apr 9.
    • von Stengel S, Bebenek M, Engelke K, Kemmler W. Whole-Body Electromyostimulation to Fight Osteopenia in Elderly Females: The Randomized Controlled Training and Electrostimulation Trial (TEST-III). J Osteoporos. 2015;2015:643520. doi: 10.1155/2015/643520. Epub 2015 Feb 15.
    • Jobse I, Liao Y, Bartram M, Delantonio K, Uter W, Stehle P, Sieber CC, Volkert D. Compliance of nursing home residents with a nutrient- and energy-dense oral nutritional supplement determines effects on nutritional status. J Nutr Health Aging. 2015;19(3):356-64. doi: 10.1007/s12603-014-0544-y.
    • Engelke K, Fuerst T, Dardzinski B, Kornak J, Ather S, Genant HK, de Papp A. Odanacatib treatment affects trabecular and cortical bone in the femur of postmenopausal women: results of a two-year placebo-controlled trial. J Bone Miner Res. 2015 Jan;30(1):30-8. doi: 10.1002/jbmr.2292.
    • Yorgan TA, Peters S, Jeschke A, Benisch P, Jakob F, Amling M, Schinke T. The Anti-Osteoanabolic Function of Sclerostin Is Blunted in Mice Carrying a High Bone Mass Mutation of Lrp5. J Bone Miner Res. 2015 Jul;30(7):1175-83. doi: 10.1002/jbmr.2461. Epub 2015 Jun 8.
    • Museyko O, Marshall RP, Lu J, Hess A, Schett G, Amling M, Kalender WA, Engelke K. Registration of 2D histological sections with 3D micro-CT datasets from small animal vertebrae and tibiae. Comput Methods Biomech Biomed Engin. 2015 Nov;18(15):1658-73. doi: 10.1080/10255842.2014.941824. Epub 2014 Aug 19.
    • Wehrle E, Liedert A, Heilmann A, Wehner T, Bindl R, Fischer L, Haffner-Luntzer M, Jakob F, Schinke T, Amling M, Ignatius A. The impact of low-magnitude high-frequency vibration on fracture healing is profoundly influenced by the oestrogen status in mice. Dis Model Mech. 2015 Jan;8(1):93-104. doi: 10.1242/dmm.018622. Epub 2014 Nov 7.
    Originalarbeiten 2014
    • Gayetskyy S, Museyko O, Käßer J, Hess A, Schett G, Engelke K. Characterization and quantification of angiogenesis in rheumatoid arthritis in a mouse model using μCT. BMC Musculoskelet Disord. 2014 Sep 6;15:298. doi: 10.1186/1471-2474-15-298.
    • Drey M, Sieber CC, Degens H, McPhee J, Korhonen MT, Müller K, Ganse B, Rittweger J. Relation between muscle mass, motor units and type of training in master athletes. Clin Physiol Funct Imaging. 2016 Jan;36(1):70-6. doi: 10.1111/cpf.12195. Epub 2014 Oct 24.
    • Djukic M, Nau R, Sieber C. [The ageing immune system]. Dtsch Med Wochenschr. 2014 Oct;139(40):1987-90. doi: 10.1055/s-0034-1370283. Epub 2014 Sep 25. Review. German.
    • Popken J, Brero A, Koehler D, Schmid VJ, Strauss A, Wuensch A, Guengoer T, Graf A, Krebs S, Blum H, Zakhartchenko V, Wolf E, Cremer T. Reprogramming of fibroblast nuclei in cloned bovine embryos involves major structural remodeling with both striking similarities and differences to nuclear phenotypes of in vitro fertilized embryos. Nucleus. 2014;5(6):555-89. doi: 10.4161/19491034.2014.979712.
    • Gayetskyy S, Museyko O, Käßer J, Hess A, Schett G, Engelke K. Characterization and quantification of angiogenesis in rheumatoid arthritis in a mouse model using μCT. BMC Musculoskelet Disord. 2014 Sep 6;15:298. doi: 10.1186/1471-2474-15-298.
    • Lowitz T, Museyko O, Bousson V, Kalender WA, Laredo JD, Engelke K. Characterization of knee osteoarthritis-related changes in trabecular bone using texture parameters at various levels of spatial resolution-a simulation study. Bonekey Rep. 2014 Dec 3;3:615. doi: 10.1038/bonekey.2014.110. eCollection 2014.
    • Museyko O, Heinemann A, Krause M, Wulff B, Amling M, Püschel K, Glüer CC, Kalender W, Engelke K. A low-radiation exposure protocol for 3D QCT of the spine. Osteoporos Int. 2014 Mar;25(3):983-92. doi: 10.1007/s00198-013-2544-x. Epub 2013 Oct 19.
    • Liedert A, Röntgen V, Schinke T, Benisch P, Ebert R, Jakob F, Klein-Hitpass L, Lennerz JK, Amling M, Ignatius A. Osteoblast-Specific Krm2 Overexpression and Lrp5 Deficiency Have Different Effects on Fracture Healing in Mice. PLoS One. 2014 Jul 25;9(7):e103250. doi: 10.1371/journal.pone.0103250.
    • Kiesswetter E, Pohlhausen S, Uhlig K, Diekmann R, Lesser S, Uter W, Heseker H, Stehle P, Sieber CC, Volkert D. Prognostic differences of the Mini Nutritional Assessment short form and long form in relation to 1-year functional decline and mortality in community-dwelling older adults receiving home care. J Am Geriatr Soc. 2014 Mar;62(3):512-7. doi: 10.1111/jgs.12683. Epub 2014 Mar 10.
    • Schrader E, Baumgärtel C, Gueldenzoph H, Stehle P, Uter W, Sieber CC, Volkert D. Nutritional status according to mini nutritional assessment is related to functional status in geriatric patients--independent of health status. J Nutr Health Aging. 2014 Mar;18(3):257-63. doi: 10.1007/s12603-013-0394-z.
    • Drey M, Krieger B, Sieber CC, Bauer JM, Hettwer S, Bertsch T; DISARCO Study Group. Motoneuron loss is associated with sarcopenia. J Am Med Dir Assoc. 2014 Jun;15(6):435-9. doi: 10.1016/j.jamda.2014.02.002. Epub 2014 Mar 18.
    • Smoliner C, Sieber CC, Wirth R. Prevalence of sarcopenia in geriatric hospitalized patients. J Am Med Dir Assoc. 2014 Apr;15(4):267-72. doi: 10.1016/j.jamda.2013.11.027.
    • Djukic M, Onken ML, Schütze S, Redlich S, Götz A, Hanisch UK, Bertsch T, Ribes S, Hanenberg A, Schneider S, Bollheimer C, Sieber C, Nau R. Vitamin d deficiency reduces the immune response, phagocytosis rate, and intracellular killing rate of microglial cells. Infect Immun. 2014 Jun;82(6):2585-94. doi: 10.1128/IAI.01814-14. Epub 2014 Mar 31.
    • Fellner C, Schick F, Kob R, Hechtl C, Vorbuchner M, Büttner R, Hamer OW, Sieber CC, Stroszczynski C, Bollheimer LC. Diet-induced and age-related changes in the quadriceps muscle: MRI and MRS in a rat model of sarcopenia. Gerontology. 2014;60(6):530-8. doi: 10.1159/000360289. Epub 2014 Jun 11.
    • Klymiuk N, Fezert P, Wünsch A, Kurome M, Kessler B, Wolf E. Homologous recombination contributes to the repair of zinc-finger-nuclease induced double strand breaks in pig primary cells and facilitates recombination with exogenous DNA. J Biotechnol. 2014 May 10;177:74-81. doi: 10.1016/j.jbiotec.2014.01.018. Epub 2014 Mar 5.
    • Graf A, Krebs S, Zakhartchenko V, Schwalb B, Blum H, Wolf E. Fine mapping of genome activation in bovine embryos by RNA sequencing. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4139-44. doi: 10.1073/pnas.1321569111. Epub 2014 Mar 3.
    • Stratmann AT, Fecher D, Wangorsch G, Göttlich C, Walles T, Walles H, Dandekar T, Dandekar G, Nietzer SL. Establishment of a human 3D lung cancer model based on a biological tissue matrix combined with a Boolean in silico model. Mol Oncol. 2014 Mar;8(2):351-65. doi: 10.1016/j.molonc.2013.11.009. Epub 2013 Dec 18.
    • Hoppensack A, Kazanecki CC, Colter D, Gosiewska A, Schanz J, Walles H, Schenke-Layland K. A human in vitro model that mimics the renal proximal tubule. Tissue Eng Part C Methods. 2014 Jul;20(7):599-609. doi: 10.1089/ten.TEC.2013.0446. Epub 2014 Jan 3.
    • Zhao H, Heusler E, Jones G, Li L, Werner V, Germershaus O, Ritzer J, Luehmann T, Meinel L. Decoration of silk fibroin by click chemistry for biomedical application. J Struct Biol. 2014 Jun;186(3):420-30. doi: 10.1016/j.jsb.2014.02.009. Epub 2014 Feb 24.
    • Germershaus O, Werner V, Kutscher M, Meinel L. Deciphering the mechanism of protein interaction with silk fibroin for drug delivery systems. Biomaterials. 2014 Mar;35(10):3427-34. doi: 10.1016/j.biomaterials.2013.12.083. Epub 2014 Jan 22.
    • Toh ML, Bonnefoy JY, Accart N, Cochin S, Pohle S, Haegel H, De Meyer M, Zemmour C, Preville X, Guillen C, Thioudellet C, Ancian P, Lux A, Sehnert B, Nimmerjahn F, Voll RE, Schett G. Bone- and cartilage-protective effects of a monoclonal antibody against colony-stimulating factor 1 receptor in experimental arthritis. Arthritis Rheumatol. 2014 Nov;66(11):2989-3000. doi: 10.1002/art.38624.
    • D'Agostino MA, Boers M, Kirwan J, van der Heijde D, Østergaard M, Schett G, Landewé RB, Maksymowych WP, Naredo E, Dougados M, Iagnocco A, Bingham CO 3rd, Brooks PM, Beaton DE, Gandjbakhch F, Gossec L, Guillemin F, Hewlett SE, Kloppenburg M, March L, Mease PJ, Moller I, Simon LS, Singh JA, Strand V, Wakefield RJ, Wells GA, Tugwell P, Conaghan PG. Updating the OMERACT filter: implications for imaging and soluble biomarkers. J Rheumatol. 2014 May;41(5):1016-24. doi: 10.3899/jrheum.131313. Epub 2014 Mar 1.
    • Beyer C, Zampetaki A, Lin NY, Kleyer A, Perricone C, Iagnocco A, Distler A, Langley SR, Gelse K, Sesselmann S, Lorenzini R, Niemeier A, Swoboda B, Distler JH, Santer P, Egger G, Willeit J, Mayr M, Schett G, Kiechl S. Signature of circulating microRNAs in osteoarthritis. Ann Rheum Dis. 2015 Mar;74(3):e18. doi: 10.1136/annrheumdis-2013-204698. Epub 2014 Feb 10.
    • Lapa C, Genest F, Buck AK, Herrmann K, Kenn W, Rudert M, Jakob F, Seefried L. Diagnostic findings and treatment in a 51-year-old woman with oncogenic osteomalacia. J Clin Endocrinol Metab. 2014 Feb;99(2):385-6. doi: 10.1210/jc.2013-3980. Epub 2013 Dec 11.
    • Wehrle E, Wehner T, Heilmann A, Bindl R, Claes L, Jakob F, Amling M, Ignatius A. Distinct frequency dependent effects of whole-body vibration on non-fractured bone and fracture healing in mice. J Orthop Res. 2014 Aug;32(8):1006-13. doi: 10.1002/jor.22629. Epub 2014 Apr 14.
    • Harre U, Kittan NA, Schett G. Autoantibody-Mediated Bone Loss. Curr Osteoporos Rep. 2014 Jan 10.
    • Töpfer D, Finzel S, Museyko O, Schett G, Engelke K. Segmentation and quantification of bone erosions in high-resolution peripheral quantitative computed tomography datasets of the metacarpophalangeal joints of patients with rheumatoid arthritis. Rheumatology (Oxford). 2014 Jan;53(1):65-71. doi: 10.1093/rheumatology/ket259. Epub 2013 Jul 27.
    • Kemmler W, Bebenek M, Engelke K, von Stengel S. Impact of whole-body electromyostimulation on body composition in elderly women at risk for sarcopenia: the Training and ElectroStimulation Trial (TEST-III). Age (Dordr). 2014 Feb;36(1):395-406. doi: 10.1007/s11357-013-9575-2. Epub 2013 Aug 16.
    • Wolf E, Braun-Reichhart C, Streckel E, Renner S. Genetically engineered pig models for diabetes research. Transgenic Res. 2014 Feb;23(1):27-38. doi: 10.1007/s11248-013-9755-y. Epub 2013 Sep 25.
    Originalarbeiten 2013
    • Vörsmann H, Groeber F, Walles H, Busch S, Beissert S, Walczak H, Kulms D. Development of a human three-dimensional organotypic skin-melanoma spheroid model for in vitro drug testing. Cell Death Dis. 2013 Jul 11;4:e719. doi: 10.1038/cddis.2013.249.
    • Wittmann K, Storck K, Muhr C, Mayer H, Regn S, Staudenmaier R, Wiese H, Maier G, Bauer-Kreisel P, Blunk T. Development of volume-stable adipose tissue constructs using polycaprolactone-based polyurethane scaffolds and fibrin hydrogels. J Tissue Eng Regen Med. 2013 Oct 30.
    • Berrut G, Andrieu S, Araujo de Carvalho I, Baeyens JP, Bergman H, Cassim B, Cerreta F, Cesari M, Cha HB, Chen LK, Cherubini A, Chou MY, Cruz-Jentoft AJ, De Decker L, Du P, Forette B, Forette F, Franco A, Guimaraes R, Guttierrez-Robledo LM, Jauregui J, Khavinson V, Lee WJ, Peng LN, Perret-Guillaume C, Petrovic M, Retornaz F, Rockwood K, Rodriguez-Manas L, Sieber C, Spatharakis G, Theou O, Topinkova E, Vellas B, Benetos A. Promoting Access to Innovation for Frail Old Persons. IAGG (International Association of Gerontology and Geriatrics), WHO (World Health Organization) and SFGG (Société Française de Gériatrie et de Gérontologie) Workshop - Athens January 20-21, 2012 Tool (GFST). J Nutr Health Aging. 2013;17(8):688-93. doi: 10.1007/s12603-013-0039-2.
    • Freiberger E, Sieber C. [Mobility in old age: aspects of training in independently living older people]. Dtsch Med Wochenschr. 2013 Oct;138(40):2007-10. doi: 10.1055/s-0033-1349508. Epub 2013 Sep 24. 
    • Biber R, Singler K, Curschmann-Horter M, Wicklein S, Sieber C, Bail HJ. Implementation of a co-managed Geriatric Fracture Center reduces hospital stay and time-to-operation in elderly femoral neck fracture patients. Arch Orthop Trauma Surg. 2013 Nov;133(11):1527-31. doi: 10.1007/s00402-013-1845-z. Epub 2013 Sep 1.
    • Scharla S, Oertel H, Petto H, Jakob F. Frakturen, Rückenschmerzen, Lebensqualität und Compliance unter einer Teriparatid-Therapie bei Patientinnen mit postmenopausaler Osteoporose in Deutschland - Subgruppen-Analyse der prospektiven europäischen Langzeit Anwendungsbeobachtung EFOS1 (Fractures, back pain, quality of life, and compliance in German postmenopausal patients with osteoporosis treated with teriparatide Subgroup analysis of the European Forsteo® Observational Study (EFOS). Osteologie / Osteology 2013 22 3: 214-222
    • Bollwein J, Diekmann R, Kaiser MJ, Bauer JM, Uter W, Sieber CC, Volkert D. Distribution but not amount of protein intake is associated with frailty: a cross-sectional investigation in the region of Nürnberg. Nutr J. 2013 Aug 5;12(1):109. doi: 10.1186/1475-2891-12-109.
    • Bauer J, Biolo G, Cederholm T, Cesari M, Cruz-Jentoft AJ, Morley JE, Phillips  S, Sieber C, Stehle P, Teta D, Visvanathan R, Volpi E, Boirie Y. Evidence-based recommendations for optimal dietary protein intake in older people: a position paper from the PROT-AGE Study Group. J Am Med Dir Assoc. 2013 Aug;14(8):542-59. doi: 10.1016/j.jamda.2013.05.021. Epub 2013 Jul 16.
    • Sehnert B, Burkhardt H, Wessels JT, Schröder A, May MJ, Vestweber D, Zwerina J, Warnatz K, Nimmerjahn F, Schett G, Dübel S, Voll RE. NF-κB inhibitor targeted to activated endothelium demonstrates a critical role of endothelial NF-κB in immune-mediated diseases. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16556-61. doi: 10.1073/pnas.1218219110. Epub 2013 Sep 23.
    • Lange U, Teichmann J, Schett G, Neumann E, Müller-Ladner U. [Osteoimmunology: How inflammation influences bone metabolism]. Dtsch Med Wochenschr. 2013 Sep;138(37):1845-9. doi: 10.1055/s-0033-1349486. Epub 2013 Sep 4. German.
    • Kocijan R, Harre U, Schett G. ACPA and Bone Loss in Rheumatoid Arthritis. Curr Rheumatol Rep. 2013 Oct;15(10):366. doi: 10.1007/s11926-013-0366-7. 
    • Engelke K, Nagase S, Fuerst T, Small M, Kuwayama T, Deacon S, Eastell R, Genant HK. The effect of the cathepsin K inhibitor ONO-5334 on trabecular and cortical bone in postmenopausal osteoporosis: the OCEAN study. J Bone Miner Res. 2014 Mar;29(3):629-38. doi: 10.1002/jbmr.2080.
    • Kocijan R, Finzel S, Englbrecht M, Engelke K, Rech J, Schett G. Differences in bone structure between rheumatoid arthritis and psoriatic arthritis patients relative to autoantibody positivity. Ann Rheum Dis. 2014 Nov;73(11):2022-8. doi: 10.1136/annrheumdis-2013-203791. Epub 2013 Aug 7.
    • Stock M, Böhm C, Scholtysek C, Englbrecht M, Fürnrohr BG, Klinger P, Gelse K, Gayetskyy S, Engelke K, Billmeier U, Wirtz S, van den Berg W, Schett G. Wnt Inhibitory Factor 1 Deficiency Uncouples Cartilage and Bone Destruction in Tumor Necrosis Factor α-Mediated Experimental Arthritis. Arthritis Rheum. 2013 Sep;65(9):2310-22. doi: 10.1002/art.38054.
    • Engelke K, Libanati C, Fuerst T, Zysset P, Genant HK. Advanced CT based In Vivo Methods for the Assessment of Bone Density, Structure, and Strength. Curr Osteoporos Rep. 2013 Sep;11(3):246-55. doi: 10.1007/s11914-013-0147-2.
    • Klymiuk N, Blutke A, Graf A, Krause S, Burkhardt K, Wuensch A, Krebs S, Kessler B, Zakhartchenko V, Kurome M, Kemter E, Nagashima H, Schoser B, Herbach N, Blum H, Wanke R, Aartsma-Rus A, Thirion C, Lochmüller H, Walter MC, Wolf E. Dystrophin-deficient pigs provide new insights into the hierarchy of physiological derangements of dystrophic muscle. Hum Mol Genet. 2013 Nov 1;22(21):4368-82. doi: 10.1093/hmg/ddt287. Epub 2013 Jun 19.
    • Kohler J, Popov C, Klotz B, Alberton P, Prall WC, Haasters F, Müller-Deubert S, Ebert R, Klein-Hitpass L, Jakob F, Schieker M, Docheva D. Uncovering the cellular and molecular changes in tendon stem/progenitor cells attributed to tendon aging and degeneration. Aging Cell. 2013 Dec;12(6):988-99. doi: 10.1111/acel.12124. Epub 2013 Jul 22.
    • Bauer J, Biolo G, Cederholm T, Cesari M, Cruz-Jentoft AJ, Morley JE, Phillips S, Sieber C, Stehle P, Teta D, Visvanathan R, Volpi E, Boirie Y. Evidence-based recommendations for optimal dietary protein intake in older people: a position paper from the PROT-AGE Study Group. J Am Med Dir Assoc. 2013 Aug;14(8):542-59. doi: 10.1016/j.jamda.2013.05.021. Epub 2013 Jul 16.
    • Popov C, Radic T, Haasters F, Prall WC, Aszodi A, Gullberg D, Schieker M, Docheva D. Integrins α2β1 and α11β1 regulate the survival of mesenchymal stem cells on collagen I. Cell Death Dis. 2011 Jul 28;2:e186. doi: 10.1038/cddis.2011.71.
    • Stange I, Bartram M, Liao Y, Poeschl K, Kolpatzik S, Uter W, Sieber CC, Stehle P, Volkert D. Effects of a low-volume, nutrient- and energy-dense oral nutritional supplement on nutritional and functional status: a randomized, controlled trial in nursing home residents. J Am Med Dir Assoc. 2013 Aug;14(8):628.e1-8. doi: 10.1016/j.jamda.2013.05.011. Epub 2013 Jun 25.
    • Diekmann R, Winning K, Bauer JM, Uter W, Stehle P, Lesser S, Bertsch T, Sieber CC, Volkert D. Vitamin D status and physical function in nursing home residents: a 1-year observational study. Z Gerontol Geriatr. 2013 Jul;46(5):403-9. doi: 10.1007/s00391-013-0507-7.
    • Keaveny TM, McClung MR, Genant HK, Zanchetta JR, Kendler D, Brown JP, Goemaere S, Recknor C, Brandi ML, Eastell R, Kopperdahl DL, Engelke K, Fuerst T, Radcliffe HS, Libanati C. Femoral and vertebral strength improvements in postmenopausal women with osteoporosis treated with denosumab. J Bone Miner Res. 2014 Jan;29(1):158-65. doi: 10.1002/jbmr.2024.
    • Tomcik M, Zerr P, Pitkowski J, Palumbo-Zerr K, Avouac J, Distler O, Becvar R, Senolt L, Schett G, Distler JH. Heat shock protein 90 (Hsp90) inhibition targets canonical TGF-β signalling to prevent fibrosis. Ann Rheum Dis. 2014 Jun;73(6):1215-22. doi: 10.1136/annrheumdis-2012-203095. Epub 2013 May 9.
    • Chen XX, Baum W, Dwyer D, Stock M, Schwabe K, Ke HZ, Stolina M, Schett G, Bozec A. Sclerostin inhibition reverses systemic, periarticular and local bone loss in arthritis. Ann Rheum Dis. 2013 Oct;72(10):1732-6. doi: 10.1136/annrheumdis-2013-203345. Epub 2013 May 10.
    • Ruiz-Heiland G, Zhao Y, Derer A, Braun T, Engelke K, Neumann E, Mueller-Ladner U, Liu Y, Zwerina J, Schett G. Deletion of the receptor tyrosine kinase Tyro3 inhibits synovial hyperplasia and bone damage in arthritis. Ann Rheum Dis. 2014 Apr;73(4):771-9. doi: 10.1136/annrheumdis-2012-202907. Epub 2013 Apr 30.
    • Herz B, Albrecht A, Englbrecht M, Welsch GH, Uder M, Renner N, Schlechtweg P, Paul D, Lauer L, Engelke K, Janka R, Rech J, Schett G, Finzel S. Osteitis and synovitis, but not bone erosion, is associated with proteoglycan loss and microstructure damage in the cartilage of patients with rheumatoid arthritis. Ann Rheum Dis. 2014 Jun;73(6):1101-6. doi: 10.1136/annrheumdis-2012-202850. Epub 2013 Apr 26.
    • Lowitz T, Museyko O, Bousson V, Laouisset L, Kalender WA, Laredo JD, Engelke K. Bone marrow lesions identified by MRI in knee osteoarthritis are associated with locally increased bone mineral density measured by QCT. Osteoarthritis Cartilage. 2013 Jul;21(7):957-64. doi: 10.1016/j.joca.2013.04.006. Epub 2013 Apr 18. 
    • Kurome M, Geistlinger L, Kessler B, Zakhartchenko V, Klymiuk N, Wuensch A, Richter A, Baehr A, Kraehe K, Burkhardt K, Flisikowski K, Flisikowska T, Merkl C, Landmann M, Durkovic M, Tschukes A, Kraner S, Schindelhauer D, Petri T, Kind A, Nagashima H, Schnieke A, Zimmer R, Wolf E. Factors influencing the efficiency of generating genetically engineered pigs by nuclear transfer: multi-factorial analysis of a large data set. BMC Biotechnol. 2013 May 20;13:43. doi: 10.1186/1472-6750-13-43.
    • Audran M, Jakob FJ, Palacios S, Brandi ML, Bröll H, Hamdy NA, McCloskey EV. A large prospective European cohort study of patients treated with strontium ranelate and followed up over 3 years. Rheumatol Int. 2013 Sep;33(9):2231-9. doi: 10.1007/s00296-012-2594-y. Epub 2013 Mar 2.
    • Venit T, Dzijak R, Kalendová A, Kahle M, Rohožková J, Schmidt V, Rülicke T, Rathkolb B, Hans W, Bohla A, Eickelberg O, Stoeger T, Wolf E, Yildirim AÖ, Gailus-Durner V, Fuchs H, de Angelis MH, Hozák P. Mouse nuclear Myosin I knock-out shows interchangeability and redundancy of Myosin isoforms in the cell nucleus. PLoS One. 2013 Apr 11;8(4):e61406. doi: 10.1371/journal.pone.0061406. Print 2013.
    • Bebbere D, Bauersachs S, Fürst RW, Reichenbach HD, Reichenbach M, Medugorac I, Ulbrich SE, Wolf E, Ledda S, Hiendleder S. Tissue-Specific and Minor Inter-Individual Variation in Imprinting of IGF2R Is a Common Feature of Bos taurus Concepti and Not Correlated with Fetal Weight. PLoS One. 2013 Apr 8;8(4):e59564. doi: 10.1371/journal.pone.0059564. Print 2013.
    • Scholtysek C, Katzenbeisser J, Fu H, Uderhardt S, Ipseiz N, Stoll C, Zaiss MM, Stock M, Donhauser L, Böhm C, Kleyer A, Hess A, Engelke K, David JP, Djouad F, Tuckermann JP, Desvergne B, Schett G, Krönke G. PPARβ/δ governs Wnt signaling and bone turnover. Nat Med. 2013 May;19(5):608-13. doi: 10.1038/nm.3146. Epub 2013 Mar 31.
    • Aeberli D, Schett G. Cortical remodeling during menopause, rheumatoid arthritis, glucocorticoid and bisphosphonate therapy. Arthritis Res Ther. 2013 Mar 21;15(2):208. doi: 10.1186/ar4180.
    • Stange I, Poeschl K, Stehle P, Sieber CC, Volkert D. Screening for Malnutrition in Nursing Home Residents: Comparison of Different Risk Markers and their Association to Functional Impairment. J Nutr Health Aging. 2013;17(4):357-63. doi: 10.1007/s12603-013-0021-z.
    • Bollwein J, Volkert D, Diekmann R, Kaiser MJ, Uter W, Vidal K, Sieber CC, Bauer JM. Nutritional Status According to the Mini Nutritional Assessment (MNA®) and Frailty in Community Dwelling Older Persons: A Close Relationship. J Nutr Health Aging. 2013;17(4):351-6. doi: 10.1007/s12603-013-0009-8.
    • Diekmann R, Winning K, Uter W, Kaiser MJ, Sieber CC, Volkert D, Bauer JM. Screening for Malnutrition among Nursing Home Residents - A Comparative Analysis of the Mini Nutritional Assessment, the Nutritional Risk Screening, and the Malnutrition Universal Screening Tool. J Nutr Health Aging. 2013;17(4):326-31. doi: 10.1007/s12603-012-0396-2.
    • Kiesswetter E, Pohlhausen S, Uhlig K, Diekmann R, Lesser S, Heseker H, Stehle P, Sieber CC, Volkert D. Malnutrition is related to functional impairment in older adults receiving home care. J Nutr Health Aging. 2013;17(4):345-50. doi: 10.1007/s12603-012-0409-1.
    • Nicks KM, Amin S, Melton LJ 3rd, Atkinson EJ, McCready LK, Riggs BL, Engelke K, Khosla S. Three-dimensional structural analysis of the proximal femur in an age-stratified sample of women. Bone. 2013 Jul;55(1):179-88. doi: 10.1016/j.bone.2013.02.009. Epub 2013 Feb 26.
    • Brixen K, Chapurlat R, Cheung AM, Keaveny TM, Fuerst T, Engelke K, Recker R, Dardzinski B, Verbruggen N, Ather S, Rosenberg E, de Papp AE. Bone density, turnover, and estimated strength in postmenopausal women treated with odanacatib: a randomized trial. J Clin Endocrinol Metab. 2013 Feb;98(2):571-80. doi: 10.1210/jc.2012-2972. Epub 2013 Jan 21.
    • Drey M, Grösch C, Neuwirth C, Bauer JM, Sieber CC. The Motor Unit Number Index (MUNIX) in sarcopenic patients. Exp Gerontol. 2013 Apr;48(4):381-4. doi: 10.1016/j.exger.2013.01.011. Epub 2013 Jan 31.
    • Baumbach SF, Fasser M, Polzer H, Sieb M, Regauer M, Mutschler W, Schieker M, Blauth M. Study protocol: the effect of whole body vibration on acute unilateral unstable lateral ankle sprain- a biphasic randomized controlled trial. BMC Musculoskelet Disord. 2013 Jan 14;14:22. doi: 10.1186/1471-2474-14-22.
    • Singh S, Zilkowski I, Ewald A, Maurell-Lopez T, Albrecht K, Möller M, Groll J. Mild oxidation of thiofunctional polymers to cytocompatible and stimuli-sensitive hydrogels and nanogels. Macromol Biosci. 2013 Apr;13(4):470-82. doi: 10.1002/mabi.201200389. Epub 2013 Feb 7.
    • Singh S, Topuz F, Hahn K, Albrecht K, Groll J. Embedding of Active Proteins and Living Cells in Redox-Sensitive Hydrogels and Nanogels through Enzymatic Cross-Linking. Angew Chem Int Ed Engl. 2013 Mar 4;52(10):3000-3. doi: 10.1002/anie.201206266. Epub 2013 Feb 5.
    • Beer MV, Rech C, Gasteier P, Sauerzapfe B, Salber J, Ewald A, Möller M, Elling L, Groll J. The Next Step in Biomimetic Material Design: Poly-LacNAc-Mediated Reversible Exposure of Extra Cellular Matrix Components. Adv Healthc Mater. 2013 Feb;2(2):306-11. doi: 10.1002/adhm.201200080. Epub 2012 Oct 2.
    Selected publications of the FORMOsA Consortium ahead of project start

    Sarcopenia and Geriatrics

    • Zech A, Drey M, Freiberger E, Hentschke C, Bauer JM, Sieber CC, Pfeifer K. Residual effects of muscle strength and muscle power training and detraining on physical function in community-dwelling prefrail older adults: a randomized controlled trial. BMC Geriatr. 2012 Nov 7;12:68. doi: 10.1186/1471-2318-12-68. 
    • Bollheimer LC, Buettner R, Pongratz G, Brunner-Ploss R, Hechtl C, Banas M, Singler K, Hamer OW, Stroszczynski C, Sieber CC, Fellner C. Sarcopenia in the aging high-fat fed rat: a pilot study for modeling sarcopenic obesity in rodents. Biogerontology. 2012 Dec;13(6):609-20. doi: 10.1007/s10522-012-9405-4. Epub 2012 Oct 14.
    • Bollwein J, Diekmann R, Kaiser MJ, Bauer JM, Uter W, Sieber CC, Volkert D. Dietary quality is related to frailty in community-dwelling older adults. J Gerontol A Biol Sci Med Sci. 2013 Apr;68(4):483-9. doi: 10.1093/gerona/gls204. Epub 2012 Oct 12.
    • Cesari M, Fielding RA, Pahor M, Goodpaster B, Hellerstein M, Van Kan GA, Anker SD, Rutkove S, Vrijbloed JW, Isaac M, Rolland Y, M'rini C, Aubertin-Leheudre M, Cedarbaum JM, Zamboni M, Sieber CC, Laurent D, Evans WJ, Roubenoff R, Morley JE,  Vellas B; International Working Group on Sarcopenia. Biomarkers of sarcopenia in clinical trials-recommendations from the International Working Group on Sarcopenia. J Cachexia Sarcopenia Muscle. 2012 Sep;3(3):181-90. doi: 10.1007/s13539-012-0078-2. Epub 2012 Aug 3.
    • Drey M, Sieber CC, Bauer JM, Uter W, Dahinden P, Fariello RG, Vrijbloed JW; FiAT intervention group. C-terminal Agrin Fragment as a potential marker for sarcopenia caused by degeneration of the neuromuscular junction. Exp Gerontol. 2013 Jan;48(1):76-80. doi: 10.1016/j.exger.2012.05.021. Epub 2012 Jun 7.
    • Meynial-Denis D, Guérin O, Schneider SM, Volkert D, Sieber CC. New Strategies  to Fight against Sarcopenia at Old Age. J Aging Res. 2012;2012:676042. doi: 10.1155/2012/676042. Epub 2012 Apr 26.
    • Hettwer S, Dahinden P, Kucsera S, Farina C, Ahmed S, Fariello R, Drey M, Sieber CC, Vrijbloed JW. Elevated levels of a C-terminal agrin fragment identifies a new subset of sarcopenia patients. Exp Gerontol. 2013 Jan;48(1):69-75. doi: 10.1016/j.exger.2012.03.002. Epub 2012 Mar 11.
    • Cooper C, Dere W, Evans W, Kanis JA, Rizzoli R, Sayer AA, Sieber CC, Kaufman JM, Abellan van Kan G, Boonen S, Adachi J, Mitlak B, Tsouderos Y, Rolland Y, Reginster JY. Frailty and sarcopenia: definitions and outcome parameters. Osteoporos Int. 2012 Jul;23(7):1839-48. doi: 10.1007/s00198-012-1913-1. Review.
    • Drey M, Zech A, Freiberger E, Bertsch T, Uter W, Sieber CC, Pfeifer K, Bauer JM. Effects of strength training versus power training on physical performance in prefrail community-dwelling older adults. Gerontology. 2012;58(3):197-204. doi: 10.1159/000332207. Epub 2011 Nov 3.
    • Kaiser MJ, Bauer JM, Uter W, Donini LM, Stange I, Volkert D, Diekmann R, Drey M, Bollwein J, Tempera S, Guerra A, Ricciardi LM, Sieber CC. Prospective validation of the modified mini nutritional assessment short-forms in the community, nursing home, and rehabilitation setting. J Am Geriatr Soc. 2011 Nov;59(11):2124-8. doi: 10.1111/j.1532-5415.2011.03659.x. Epub 2011 Sep 21.
    • Volkert D, Sieber CC. Protein requirements in the elderly. Int J Vitam Nutr Res. 2011 Mar;81(2-3):109-19. doi: 10.1024/0300-9831/a000061. Review.
    • Inzitari M, Doets E, Bartali B, Benetou V, Di Bari M, Visser M, Volpato S, Gambassi G, Topinkova E, De Groot L, Salva A; International Association Of Gerontology And Geriatrics (IAGG) Task Force For Nutrition In The Elderly. Nutrition in the age-related disablement process. J Nutr Health Aging. 2011 Aug;15(8):599-604. Review.
    • Cederholm TE, Bauer JM, Boirie Y, Schneider SM, Sieber CC, Rolland Y. Toward a definition of sarcopenia. Clin Geriatr Med. 2011 Aug;27(3):341-53. doi: 10.1016/j.cger.2011.04.001. Epub 2011 Jun 8. 
    • Chumlea WC, Cesari M, Evans WJ, Ferrucci L, Fielding RA, Pahor M, Studenski S, Vellas B; International Working Group on Sarcopenia Task Force Members. Sarcopenia: designing phase IIB trials. J Nutr Health Aging. 2011 Jun;15(6):450-5.
    • Fielding RA, Vellas B, Evans WJ, Bhasin S, Morley JE, Newman AB, Abellan van Kan G, Andrieu S, Bauer J, Breuille D, Cederholm T, Chandler J, De Meynard C, Donini L, Harris T, Kannt A, Keime Guibert F, Onder G, Papanicolaou D, Rolland Y, Rooks D, Sieber C, Souhami E, Verlaan S, Zamboni M. Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc. 2011 May;12(4):249-56. doi: 10.1016/j.jamda.2011.01.003. Epub 2011 Mar 4.

    Chronic inflammatory disorders

    • Kleyer A, Finzel S, Rech J, Manger B, Krieter M, Faustini F, Araujo E, Hueber AJ, Harre U, Engelke K, Schett G. Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies. Ann Rheum Dis. 2014 May;73(5):854-60. doi: 10.1136/annrheumdis-2012-202958. Epub 2013 Mar 21.
    • Kiechl S, Wittmann J, Giaccari A, Knoflach M, Willeit P, Bozec A, Moschen AR, Muscogiuri G, Sorice GP, Kireva T, Summerer M, Wirtz S, Luther J, Mielenz D, Billmeier U, Egger G, Mayr A, Oberhollenzer F, Kronenberg F, Orthofer M, Penninger JM, Meigs JB, Bonora E, Tilg H, Willeit J, Schett G. Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus. Nat Med. 2013 Feb 10;19(3):358-63. doi: 10.1038/nm.3084. Epub 2013 Feb 10.
    • Englbrecht M, Kruckow M, Araujo E, Rech J, Schett G. The interaction of physical function and emotional well-being in rheumatoid arthritis--what is the impact on disease activity and coping? Semin Arthritis Rheum. 2013 Apr;42(5):482-91. doi: 10.1016/j.semarthrit.2012.09.003. Epub 2013 Jan 29
    • Harre U, Schett G. Bone research in 2012: the ups and downs of bone in health and rheumatic disease. Nat Rev Rheumatol. 2013 Feb;9(2):67-8. doi: 10.1038/nrrheum.2012.219. Epub 2013 Jan 8.
    • Lories RJ, Schett G. Pathophysiology of new bone formation and ankylosis in spondyloarthritis. Rheum Dis Clin North Am. 2012 Aug;38(3):555-67. doi: 10.1016/j.rdc.2012.08.003. Epub 2012 Sep 7.
    • Schett G, Gravallese E. Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment. Nat Rev Rheumatol. 2012 Nov;8(11):656-64. doi: 10.1038/nrrheum.2012.153. Epub 2012 Sep 25.
    • Kleyer A, Scholtysek C, Bottesch E, Hillienhof U, Beyer C, Distler JH, Tuckermann JP, Schett G, Krönke G. Liver X receptors orchestrate osteoblast/osteoclast crosstalk and counteract pathologic bone loss. J Bone Miner Res. 2012 Dec;27(12):2442-51. doi: 10.1002/jbmr.1702.
    • Rauner M, Stein N, Winzer M, Goettsch C, Zwerina J, Schett G, Distler JH, Albers J, Schulze J, Schinke T, Bornhäuser M, Platzbecker U, Hofbauer LC. WNT5A is induced by inflammatory mediators in bone marrow stromal cells and regulates cytokine and chemokine production. J Bone Miner Res. 2012 Mar;27(3):575-85. doi: 10.1002/jbmr.1488.
    • McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med. 2011 Dec 8;365(23):2205-19. doi: 10.1056/NEJMra1004965. Review.

    Musculoskeletal Research, Osteology and Osteoporosis

    • Hofmann C, Liese J, Schwarz T, Kunzmann S, Wirbelauer J, Nowak J, Hamann J, Girschick H, Graser S, Dietz K, Zeck S, Jakob F, Mentrup B. Compound heterozygosity of two functional null mutations in the ALPL gene associated with deleterious neurological outcome in an infant with hypophosphatasia. Bone. 2013 Jul;55(1):150-7. doi: 10.1016/j.bone.2013.02.017. Epub 2013 Feb 27.
    • Mentrup B, Marschall C, Barvencik F, Amling M, Plendl H, Jakob F, Beck C. Functional characterization of a novel mutation localized in the start codon of the tissue-nonspecific alkaline phosphatase gene. Bone. 2011 Jun 1;48(6):1401-8. doi: 10.1016/j.bone.2011.03.676. Epub 2011 Mar 16.
    • Schilling T, Ebert R, Raaijmakers N, Schütze N, Jakob F. Effects of phytoestrogens and other plant-derived compounds on mesenchymal stem cells, bone maintenance and regeneration. J Steroid Biochem Mol Biol. 2014 Jan;139:252-61. doi: 10.1016/j.jsbmb.2012.12.006. Epub 2012 Dec 20.
    • Benisch P, Schilling T, Klein-Hitpass L, Frey SP, Seefried L, Raaijmakers N, Krug M, Regensburger M, Zeck S, Schinke T, Amling M, Ebert R, Jakob F. The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors. PLoS One. 2012;7(9):e45142. doi: 10.1371/journal.pone.0045142. Epub 2012 Sep 24.
    • Walsh JB, Lems WF, Karras D, Langdahl BL, Ljunggren O, Fahrleitner-Pammer A, Barrett A, Rajzbaum G, Jakob F, Marin F. Effectiveness of Teriparatide in women over 75 years of age with severe osteoporosis: 36-month results from the European Forsteo Observational Study (EFOS). Calcif Tissue Int. 2012 May;90(5):373-83.doi: 10.1007/s00223-012-9590-9. Epub 2012 Apr 1.
    • Ebert R, Zeck S, Meissner-Weigl J, Klotz B, Rachner TD, Benad P, Klein-Hitpass L, Rudert M, Hofbauer LC, Jakob F. Krüppel-like factors KLF2 and 6 and Ki-67 are direct targets of zoledronic acid in MCF-7 cells. Bone. 2012 Mar;50(3):723-32. doi: 10.1016/j.bone.2011.11.025. Epub 2011 Dec 7.
    • Klotz B, Mentrup B, Regensburger M, Zeck S, Schneidereit J, Schupp N, Linden C, Merz C, Ebert R, Jakob F. 1,25-dihydroxyvitamin D3 treatment delays cellular aging in human mesenchymal stem cells while maintaining their multipotent capacity. PLoS One. 2012;7(1):e29959. doi: 10.1371/journal.pone.0029959. Epub 2012 Jan 5.
    • Jakob F, Oertel H, Langdahl B, Ljunggren O, Barrett A, Karras D, Walsh JB, Fahrleitner-Pammer A, Rajzbaum G, Barker C, Lems WF, Marin F. Effects of teriparatide in postmenopausal women with osteoporosis pre-treated with bisphosphonates: 36-month results from the European Forsteo Observational Study. Eur J Endocrinol. 2012 Jan;166(1):87-97. doi: 10.1530/EJE-11-0740. Epub 2011 Nov 2. Erratum in: Eur J Endocrinol. 2012 Mar;166(3):563.
    • Seefried L, Mueller-Deubert S, Schwarz T, Lind T, Mentrup B, Kober M, Docheva D, Liedert A, Kassem M, Ignatius A, Schieker M, Claes L, Wilke W, Jakob F, Ebert R. A small scale cell culture system to analyze mechanobiology using reporter gene constructs and polyurethane dishes. Eur Cell Mater. 2010 Dec 10;20:344-55.
    • Liedert A, Wagner L, Seefried L, Ebert R, Jakob F, Ignatius A. Estrogen receptor and Wnt signaling interact to regulate early gene expression in response to mechanical strain in osteoblastic cells. Biochem Biophys Res Commun. 2010 Apr  9;394(3):755-9. doi: 10.1016/j.bbrc.2010.03.065. Epub 2010 Mar 17.
    • Goebel S, Lienau J, Rammoser U, Seefried L, Wintgens KF, Seufert J, Duda G, Jakob F, Ebert R. FGF23 is a putative marker for bone healing and regeneration. J Orthop Res. 2009 Sep;27(9):1141-6. doi: 10.1002/jor.20857. 
    • Pietschmann MF, Frankewycz B, Schmitz P, Docheva D, Sievers B, Jansson V, Schieker M, Müller PE. Comparison of tenocytes and mesenchymal stem cells seeded on biodegradable scaffolds in a full-size tendon defect model. J Mater Sci Mater Med. 2013 Jan;24(1):211-20. doi: 10.1007/s10856-012-4791-3. Epub 2012 Oct 23.
    • Wagenhäuser MU, Pietschmann MF, Sievers B, Docheva D, Schieker M, Jansson V, Müller PE. Collagen type I and decorin expression in tenocytes depend on the cell isolation method. BMC Musculoskelet Disord. 2012 Aug 8;13:140. doi: 10.1186/1471-2474-13-140.
    • Saller MM, Prall WC, Docheva D, Schönitzer V, Popov T, Anz D, Clausen-Schaumann H, Mutschler W, Volkmer E, Schieker M, Polzer H. Increased stemness and migration of human mesenchymal stem cells in hypoxia is associated with altered integrin expression. Biochem Biophys Res Commun. 2012 Jun 29;423(2):379-85. doi: 10.1016/j.bbrc.2012.05.134. Epub 2012 Jun 1.
    • Alberton P, Popov C, Prägert M, Kohler J, Shukunami C, Schieker M, Docheva D. Conversion of human bone marrow-derived mesenchymal stem cells into tendon progenitor cells by ectopic expression of scleraxis. Stem Cells Dev. 2012 Apr 10;21(6):846-58. doi: 10.1089/scd.2011.0150. Epub 2011 Oct 11.  
    • Polzer H, Volkmer E, Saller MM, Prall WC, Haasters F, Drosse I, Anz D, Mutschler W, Schieker M. Long-term detection of fluorescently labeled human mesenchymal stem cell in vitro and in vivo by semi-automated microscopy. Tissue Eng Part C Methods. 2012 Feb;18(2):156-65. doi: 10.1089/ten.TEC.2011.0275. Epub2011 Dec 13. 
    • Gildehaus FJ, Haasters F, Drosse I, Wagner E, Zach C, Mutschler W, Cumming P,  Bartenstein P, Schieker M. Impact of indium-111 oxine labelling on viability of human mesenchymal stem cells in vitro, and 3D cell-tracking using SPECT/CT in vivo. Mol Imaging Biol. 2011 Dec;13(6):1204-14. doi: 10.1007/s11307-010-0439-1.
    • Docheva D, Padula D, Popov C, Weishaupt P, Prägert M, Miosge N, Hickel R, Böcker W, Clausen-Schaumann H, Schieker M. Establishment of immortalized periodontal ligament progenitor cell line and its behavioural analysis on smooth and rough titanium surface. Eur Cell Mater. 2010 May 14;19:228-41.

    Tissue Engineering, Materials and Bioreactors

    • Holzapfel BM, Reichert JC, Schantz JT, Gbureck U, Rackwitz L, Nöth U, Jakob F, Rudert M, Groll J, Hutmacher DW. How smart do biomaterials need to be? A translational science and clinical point of view. Adv Drug Deliv Rev. 2012 Jul 20. [Epub ahead of print] PubMed PMID: 22820527.
    • Jakob F, Ebert R, Rudert M, Nöth U, Walles H, Docheva D, Schieker M, Meinel L, Groll J. In situ guided tissue regeneration in musculoskeletal diseases and aging : Implementing pathology into tailored tissue engineering strategies. Cell Tissue Res. 2012 Mar;347(3):725-35. doi: 10.1007/s00441-011-1237-z. Epub 2011 Oct 20. Review.
    • Volkmer E, Otto S, Polzer H, Saller M, Trappendreher D, Zagar D, Hamisch S, Ziegler G, Wilhelmi A, Mutschler W, Schieker M. Overcoming hypoxia in 3D culture  systems for tissue engineering of bone in vitro using an automated, oxygen-triggered feedback loop. J Mater Sci Mater Med. 2012 Nov;23(11):2793-801. doi: 10.1007/s10856-012-4725-0. Epub 2012 Jul 29.
    • Marx U, Walles H, Hoffmann S, Lindner G, Horland R, Sonntag F, Klotzbach U, Sakharov D, Tonevitsky A, Lauster R. 'Human-on-a-chip' developments: a translational cutting-edge alternative to systemic safety assessment and efficiency evaluation of substances in laboratory animals and man? Altern Lab Anim. 2012 Oct;40(5):235-57.
    • Hansmann J, Groeber F, Kahlig A, Kleinhans C, Walles H. Bioreactors in tissue  engineering-principles, applications and commercial constraints. Biotechnol J. 2013 Mar;8(3):298-307. doi: 10.1002/biot.201200162. Epub 2012 Nov 19.
    • Groeber F, Kahlig A, Loff S, Walles H, Hansmann J. A bioreactor system for interfacial culture and physiological perfusion of vascularized tissue equivalents. Biotechnol J. 2013 Mar;8(3):308-16. doi: 10.1002/biot.201200160. Epub 2012 Nov 9.
    • Gryanik A, Wittenberg T, Walles H, Steckhan D, Thude S, Kaufmann M, Münzenmayer C. Automatic Image Quantification for Structural Analysis of in vitro Dermal Samples. Biomed Tech (Berl). 2012 Aug 24. doi:pii: /j/bmte.2012.57.issue-s1-B/bmt-2012-4241/bmt-2012-4241.xml.10.1515/bmt-2012-4241. [Epub ahead of print]
    • Scheller K, Dally I, Hartmann N, Münst B, Braspenning J, Walles H. Upcyte® microvascular endothelial cells repopulate decellularized scaffold. Tissue Eng Part C Methods. 2013 Jan;19(1):57-67. doi: 10.1089/ten.TEC.2011.0723. Epub 2012 Sep 13.
    • Votteler M, Carvajal Berrio DA, Pudlas M, Walles H, Schenke-Layland K. Non-contact, label-free monitoring of cells and extracellular matrix using Raman spectroscopy. J Vis Exp. 2012 May 29;(63). doi:pii: 3977. 10.3791/3977.
    • Votteler M, Carvajal Berrio DA, Pudlas M, Walles H, Stock UA, Schenke-Layland  K. Raman spectroscopy for the non-contact and non-destructive monitoring of collagen damage within tissues. J Biophotonics. 2012 Jan;5(1):47-56. doi: 10.1002/jbio.201100068. Epub 2011 Sep 27.
    • Pusch J, Votteler M, Göhler S, Engl J, Hampel M, Walles H, Schenke-Layland K. The physiological performance of a three-dimensional model that mimics the microenvironment of the small intestine. Biomaterials. 2011 Oct;32(30):7469-78. doi: 10.1016/j.biomaterials.2011.06.035. Epub 2011 Jul 20.
    • Popov C, Radic T, Haasters F, Prall WC, Aszodi A, Gullberg D, Schieker M, Docheva D. Integrins α2β1 and α11β1 regulate the survival of mesenchymal stem cells on collagen I. Cell Death Dis. 2011 Jul 28;2:e186. doi: 10.1038/cddis.2011.71.
    • Votteler M, Kluger PJ, Walles H, Schenke-Layland K. Stem cell microenvironments--unveiling the secret of how stem cell fate is defined. Macromol Biosci. 2010 Nov 10;10(11):1302-15. doi: 10.1002/mabi.201000102. Review.
    • Meinel L, Kaplan DL. Silk constructs for delivery of musculoskeletal therapeutics. Adv Drug Deliv Rev. 2012 Sep;64(12):1111-22. doi: 10.1016/j.addr.2012.03.016. Epub 2012 Apr 13. Review. 
    • Meinel AJ, Germershaus O, Luhmann T, Merkle HP, Meinel L. Electrospun matrices for localized drug delivery: current technologies and selected biomedical applications. Eur J Pharm Biopharm. 2012 May;81(1):1-13. doi: 10.1016/j.ejpb.2012.01.016. Epub 2012 Feb 11. Review.
    • Luhmann T, Germershaus O, Groll J, Meinel L. Bone targeting for the treatment  of osteoporosis. J Control Release. 2012 Jul 20;161(2):198-213. doi: 10.1016/j.jconrel.2011.10.001. Epub 2011 Oct 8. Review. 
    • Holzerny P, Ajdini B, Heusermann W, Bruno K, Schuleit M, Meinel L, Keller M. Biophysical properties of chitosan/siRNA polyplexes: profiling the polymer/siRNA interactions and bioactivity. J Control Release. 2012 Jan 30;157(2):297-304. doi: 10.1016/j.jconrel.2011.08.023. Epub 2011 Aug 22.
    • Wenk E, Merkle HP, Meinel L. Silk fibroin as a vehicle for drug delivery applications. J Control Release. 2011 Mar 10;150(2):128-41. doi: 10.1016/j.jconrel.2010.11.007. Epub 2010 Nov 6. Review.
    • Yildirim S, Borer ME, Wenk E, Meinel L, Lacroix C. Development of silk fibroin-based beads for immobilized cell fermentations. J Microencapsul. 2010;27(1):1-9. doi: 10.3109/02652040802217516.
    • Uebersax L, Merkle HP, Meinel L. Biopolymer-based growth factor delivery for tissue repair: from natural concepts to engineered systems. Tissue Eng Part B Rev. 2009 Sep;15(3):263-89. doi: 10.1089/ten.TEB.2008.0668. Review. 
    • Kettel MJ, Hildebrandt H, Schaefer K, Moeller M, Groll J. Tenside-free preparation of nanogels with high functional β-cyclodextrin content. ACS Nano. 2012 Sep 25;6(9):8087-93. Epub 2012 Aug 8. 
    • Krüger R, Groll J. Fiber reinforced calcium phosphate cements -- on the way to degradable load bearing bone substitutes? Biomaterials. 2012 Sep;33(25):5887-900. doi: 10.1016/j.biomaterials.2012.04.053. Epub 2012 May 25. Review.
    • Bartneck M, Heffels KH, Pan Y, Bovi M, Zwadlo-Klarwasser G, Groll J. Inducing healing-like human primary macrophage phenotypes by 3D hydrogel coated nanofibres. Biomaterials. 2012 Jun;33(16):4136-46. doi: 10.1016/j.biomaterials.2012.02.050. Epub 2012 Mar 13.
    • Grafahrend D, Heffels KH, Beer MV, Gasteier P, Möller M, Boehm G, Dalton PD, Groll J. Degradable polyester scaffolds with controlled surface chemistry combining minimal protein adsorption with specific bioactivation. Nat Mater. 2011 Jan;10(1):67-73. doi: 10.1038/nmat2904.

    Large animal cloning

    • Walters EM, Wolf E, Whyte JJ, Mao J, Renner S, Nagashima H, Kobayashi E, Zhao J, Wells KD, Critser JK, Riley LK, Prather RS. Completion of the swine genome will simplify the production of swine as a large animal biomedical model. BMC Med Genomics. 2012 Nov 15;5:55. doi: 10.1186/1755-8794-5-55.
    • Dahlhoff M, Schäfer M, Wolf E, Schneider MR. Genetic deletion of the EGFR ligand epigen does not affect mouse embryonic development and tissue homeostasis. Exp Cell Res. 2013 Feb 15;319(4):529-35. doi: 10.1016/j.yexcr.2012.11.001. Epub 2012 Nov 6.
    • Leuchs S, Saalfrank A, Merkl C, Flisikowska T, Edlinger M, Durkovic M, Rezaei  N, Kurome M, Zakhartchenko V, Kessler B, Flisikowski K, Kind A, Wolf E, Schnieke  A. Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs. PLoS One. 2012;7(10):e43323. doi: 10.1371/journal.pone.0043323. Epub 2012 Oct 5.
    • Flisikowska T, Merkl C, Landmann M, Eser S, Rezaei N, Cui X, Kurome M, Zakhartchenko V, Kessler B, Wieland H, Rottmann O, Schmid RM, Schneider G, Kind A, Wolf E, Saur D, Schnieke A. A porcine model of familial adenomatous polyposis. Gastroenterology. 2012 Nov;143(5):1173-5.e1-7. doi: 10.1053/j.gastro.2012.07.110. Epub 2012 Aug 1.
    • Bähr A, Wolf E. Domestic animal models for biomedical research. Reprod Domest  Anim. 2012 Aug;47 Suppl 4:59-71. doi: 10.1111/j.1439-0531.2012.02056.x. Review.
    • Renner S, Römisch-Margl W, Prehn C, Krebs S, Adamski J, Göke B, Blum H, Suhre K, Roscher AA, Wolf E. Changing metabolic signatures of amino acids and lipids during the prediabetic period in a pig model with impaired incretin function and reduced β-cell mass. Diabetes. 2012 Aug;61(8):2166-75. doi: 10.2337/db11-1133. Epub 2012 Apr 9.
    • Klymiuk N, Böcker W, Schönitzer V, Bähr A, Radic T, Fröhlich T, Wünsch A, Keßler B, Kurome M, Schilling E, Herbach N, Wanke R, Nagashima H, Mutschler W, Arnold GJ, Schwinzer R, Schieker M, Wolf E. First inducible transgene expression  in porcine large animal models. FASEB J. 2012 Mar;26(3):1086-99. doi: 10.1096/fj.11-185041. Epub 2011 Dec 1.
    Imaging, Measurement Techniques and exercise/intervention
    • Engelke K. Assessment of bone quality and strength with new technologies. Curr Opin Endocrinol Diabetes Obes. 2012 Dec;19(6):474-82. doi: 10.1097/MED.0b013e32835a2609.
    • Finzel S, Kraus S, Schmidt S, Hueber A, Rech J, Engelke K, Englbrecht M, Schett G. Bone anabolic changes progress in psoriatic arthritis patients despite treatment with methotrexate or tumour necrosis factor inhibitors. Ann Rheum Dis. 2013 Jul;72(7):1176-81. doi: 10.1136/annrheumdis-2012-201580. Epub 2012 Aug 21.
    • Finzel S, Rech J, Schmidt S, Engelke K, Englbrecht M, Schett G. Interleukin-6 receptor blockade induces limited repair of bone erosions in rheumatoid arthritis: a micro CT study. Ann Rheum Dis. 2013 Mar;72(3):396-400. doi: 10.1136/annrheumdis-2011-201075. Epub 2012 May 14.
    • Böhm C, Derer A, Axmann R, Hillienhoff U, Zaiss MM, Luther J, Zech C, Stock M, Scholtysek C, Engelke K, Hess A, Tuckermann JP, Schett G, David JP. RSK2 protects mice against TNF-induced bone loss. J Cell Sci. 2012 May 1;125(Pt 9):2160-71. doi: 10.1242/jcs.096008. Epub 2012 Feb 17.
    • Engelke K, Stampa B, Timm W, Dardzinski B, de Papp AE, Genant HK, Fuerst T. Short-term in vivo precision of BMD and parameters of trabecular architecture at the distal forearm and tibia. Osteoporos Int. 2012 Aug;23(8):2151-8. doi: 10.1007/s00198-011-1829-1. Epub 2011 Dec 6.
    • Kemmler W, Bebenek M, von Stengel S, Engelke K, Kalender WA. Effect of block-periodized exercise training on bone and coronary heart disease risk factors in early post-menopausal women: a randomized controlled study. Scand J Med Sci Sports. 2013 Feb;23(1):121-9. doi: 10.1111/j.1600-0838.2011.01335.x. Epub 2011 Jun 2.
    • Kemmler W, von Stengel S, Bebenek M, Engelke K, Hentschke C, Kalender WA. Exercise and fractures in postmenopausal women: 12-year results of the Erlangen Fitness and Osteoporosis Prevention Study (EFOPS). Osteoporos Int. 2012 Apr;23(4):1267-76. doi: 10.1007/s00198-011-1663-5. Epub 2011 May 28.
    • Griffith JF, Engelke K, Genant HK. Looking beyond bone mineral density : Imaging assessment of bone quality. Ann N Y Acad Sci. 2010 Mar;1192:45-56. doi: 10.1111/j.1749-6632.2009.05378.x. Review.
    • Von Stengel S, Kemmler W, Engelke K, Kalender WA. Effects of whole body vibration on bone mineral density and falls: results of the randomized controlled ELVIS study with postmenopausal women. Osteoporos Int. 2011 Jan;22(1):317-25. doi: 10.1007/s00198-010-1215-4. Epub 2010 Mar 20.

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